Peel and cut persimmons into 1cm cubes. Transfer to a bowl.
Sprinkle persimmons with 2 tbsp of the brown sugar and 1/4 tsp salt. Let sit for 20 mins. Set aside.
Preheat oven to 350 degrees F and grease and line an 8x4 in. loaf pan with parchment paper.
In the bowl of a stand mixer or a large bowl with a hand mixer, cream room temperature butter with the rest of the sugar, spices, rest of the salt, and baking powder.
Add eggs and beat until well mixed.
Take half of the cubed persimmon (leave the juice in the bowl) and add to the batter. (If you don’t like large chunks, you can pulse it a few times in a blender or food processor to make into smaller pieces).
Add flour and vanilla and gently mix.
Transfer to your loaf pan and bake for 35 minutes or until a toothpick inserted in the center comes out clean.
After cake is done, remove from pan. While still hot, spread remaining persimmon with the liquid on top.